Malvern Instruments Ltd (Malvern)

Malvern Instruments provides the materials and biophysical characterization technology and expertise that enable scientists and engineers to understand and control the properties of dispersed systems. These systems range from proteins and polymers in solution, particle and nanoparticle suspensions and emulsions, through to sprays and aerosols, industrial bulk powders and high concentration slurries. Used at all stages of research, development and manufacturing, Malvern’s materials characterization instruments provide critical information that helps accelerate research and product development, enhance and maintain product quality and optimize process efficiency.

Our products reflect Malvern’s drive to exploit the latest technological innovations and our commitment to maximizing the potential of established techniques. They are used by both industry and academia, in sectors ranging from pharmaceuticals and biopharmaceuticals to bulk chemicals, cement, plastics and polymers, energy and the environment.

Malvern systems are used to measure particle size, particle shape, zeta potential, protein charge, molecular weight, mass, size and conformation, microcalorimetry, rheological properties and for chemical identification, advancing the understanding of dispersed systems across many different industries and applications.

Headquartered in Malvern, UK, Malvern Instruments has subsidiary organizations in all major European markets, North America, Mexico, China, Japan and Korea, a joint venture in India, a global distributor network and applications laboratories around the world.

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Grovewood Road
Malvern
WR14 1XZ
UK

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Dr Patrick Hole
Principal investigator

Patrick Hole is the External Technology Leader for the NPI department of Malvern Instruments. Previously he was Engineering Manager for the NTA range of products responsible for line- and project- managing R&D hardware and software teams to effectively develop NTA technology in collaboration with product management. He has a Ph.D. in Optoelectronics from the Optoelectronics Research Centre, University of Southampton and a Master of Engineering (MEng.) degree from The Queen's College, University of Oxford. He has 50+ conference proceedings, oral contributions and journal papers and is author or co-author on several patents/patent applications.
Previously he was Head of Development, for NanoSight Limited which produces instruments for optical analysis of small particles. He has developed and successfully brought to market multiple product lines and new measurement capabilities which are typically multidisciplined including optics, fluidics, electronics, software, temperature control, motorised stages.
He has experience managed external collaborations including four EU funded grants and multiple projects with industry, universities and national institutes.

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Pauline Carnell-Morris
Deputy principal investigator

Pauline studied Pharmacology at the University of Liverpool, and has worked for large pharmaceutical companies for over 20 years (Pfizer and Warner Lambert) and also for smaller biotech organizations, in application areas ranging from assay development for GPCRs, ion channels, antibodies and proteins, through to protein-conjugated gold nanoparticles. In 2013 Pauline joined NanoSight Ltd as a Senior Application Scientist with a focus on characterizing biological nanoparticles and fluorescent nanoparticles. Following the acquisition of NanoSight by Malvern Instruments Ltd, Pauline became Product Manager for the NanoSight instrument range, translating the requirements of the nanoparticle characterization application space into user-friendly, added value data solutions to meet current and future needs. From January 2017 Pauline role has expanded to Product Manager – Bioparticle Characterization within the Bioscience Product Management group. This group is tasked with identifying and understanding market opportunities in the bioscience sector, and providing critical input into informing and developing solutions to meet current and emerging analytical measurement challenges for biologics. In this role Pauline will develop a wider view of all the analytical techniques that serve particle characterization requirements in bioscience applications, and take on the responsibility for developing and supporting a solutions portfolio targeted at meeting a range of bioparticle characterization needs.

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Agnieszka Siupa
Deputy principal investigator

Agnieszka Siupa studied Polymer Chemistry in Cracow University of Technology. In her master thesis “Physical modification of thermoplastic materials with polyaspartic acid” Agnieszka modified HDPE with biodegradable polyaminoacid using microwave reactor. Improved chemical and physical properties of modified material, especially wear resistance made this materialan attractive candidate for the orthopedic implants. After University, Agnieszka joined NanoSight as a Laboratory Assistant and was involved mainly in instrument production, customer sample analysis. During 8 years at NanoSight Agnieszka had various roles and responsibilities in all company deparments from production, product development, application research, sales to customer support. In her current role as Application Research Scientist, Agnieszka is providing the NTA application expertise to both internal and external customers, carry out an individual and collaboration research as well as works with the product development team. Being a part of Particle Characterization company, Agnieszka is gradually expanding her application expertise to other particle characterization technologies, in particular DLS and RMM. Agnieszka is interested in bio- and fluorescence application especially exosomes, drug delivery, viruses and protein aggregation.