---
title: Home
url: 'https://b-smart-project.eu/'
markdown: 'https://b-smart-project.eu/index.md'
date: '2026-11-04'
---

#  Please note: B-SMART concluded its activities in June 2022. 

# Innovative nanotechnological RNA delivery systems targeting the direct cause of Alzheimer‘s disease instead of its symptoms

Neurodegenerative diseases such as Alzheimer’s affect over 7 million people in Europe. Despite this fact, few treatments for this group of diseases are available so far. Nanomedical approaches can make a difference, providing new therapeutic options by helping drugs to enter the brain.

Therefore, the multinational research project B-SMART sets out to provide an RNA-based therapy perspective for neurodegenerative diseases targeting the direct cause of the disease instead of its symptoms in the midterm.

> "Transferring RNA therapeutics to the brain crossing the blood-cerebrospinal fluid barrier is a unique research endeavor. Finding a novel gateway to transport RNA to the brain will enable the development of causal therapies not only for Alzheimer’s, but for other diseases as well."

 ![Photo of Prof. Raymond Schiffelers](https://b-smart-project.eu/user/pages/00.home/01._text/rms.jpg "Prof. Raymond Schiffelers") 

Prof. Raymond Schiffelers (UMCU), Coordinator of B-SMART

  - Learn how far B-SMART has come in their collaborative endeavour in this new Video Clip which highlights project’s pathway to success
- Learn about our ideas and objectives: The animated B-SMART film
- Learn more about B-SMART and what working in an international research project means to the young scientists in our project

Neurodegenerative Diseases

 ![Icon 1](https://b-smart-project.eu/user/pages/00.home/03._tiles/icon-1.svg)Lack of causal therapies and effective drugs

Nanomedicines

 ![Icon 2](https://b-smart-project.eu/user/pages/00.home/03._tiles/icon-2.svg)RNA-based nanomedicines directly targeting the brain

Transport

 ![Icon 3](https://b-smart-project.eu/user/pages/00.home/03._tiles/icon-3.svg)Secure in-vivo transport through nanocarriers

Delivery

 ![Icon 4](https://b-smart-project.eu/user/pages/00.home/03._tiles/icon-4.svg)Crossing the blood-cerebrospinal fluid barrier through ligands

Proof of Concept

 ![Icon 5](https://b-smart-project.eu/user/pages/00.home/03._tiles/icon-5.svg)Basis technology for treatment of other diseases

[ Learn more](https://b-smart-project.eu/project)

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