Publications

2022

• Marie J. Pauwels, Junhua Xie, Adam Ceroi, Sriram Balusu, Jonas Castelein, Elien Van Wonterghem, Griet Van Imschoot, Andrew Ward, Trevelyan R. Menheniott, Oskar Gustafsson, Francis Combes, Samir EL Andaloussi, Niek N. Sanders, Imre Mäger, Lien Van Hoecke, Roosmarijn E. Vandenbroucke:
  Choroid plexus-derived extracellular vesicles exhibit brain targeting characteristics
  Biomaterials 290, 10.1016/j.biomaterials.2022.121830
  Additional link
  
  
• Mireya L Borrajo, María José Alonso:
  Using nanotechnology to deliver biomolecules from nose to brain—peptides, proteins, monoclonal antibodies and RNA
  Drug delivery and translational research 12, 862–880 (2022), 10.1007/s13346-021-01086-2
  
  

2021

• Hammond, S.M.; Aartsma-Rus, A.; Alves, S.; Borgos, S.E.; Buijsen, R.A.M.; Collin, R.W.J.; Covello, G.; Denti, M.A.; Desviat, L.R.; Echevarría, L.; Foged, C.; Gaina, G.; Garanto, A.; Garanto, A.; Goyenvalle, A.T.; Guzowska, M.; Holodnuka, I.; Jones, D.R.; Krause, S.; Lehto, T.; Montolio, M.; Van Roon-Mom, W.; Arechavala-Gomeza, V.:
  Delivery of oligonucleotide‐based therapeutics: challenges and opportunities
  EMBO Molecular Medicine 13(4):e13243, 10.15252/emmm.202013243
  
  
• Mariana Conceição, Laura Forcina, Oscar P.B. Wiklander, Dhanu Gupta, Joel Z. Nordin, Besarte Vrellaku, Graham McClorey, Imre Mäger, André Gӧrgens, Per Lundin, Antonio Musarò, Matthew J.A. Wood, Samir ELAndaloussi, Thomas C. Roberts:
  Engineered extracellular vesicle decoy receptor-mediated modulation of the IL6 trans-signalling pathway in muscle
  Biomaterials 266, https://doi.org/10.1016/j.biomaterials.2020.120435
  
  
• R.Mildner, S.Hak, J.Parot , A.Hyldbakk, S.E.Borgos, D.Some, C.Johann, F.Caputo:
  Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery
  European Journal of Pharmaceutics and Biopharmaceutics 163, 252-265, https://doi.org/10.1016/j.ejpb.2021.03.004
  
  
• Roy van der Meel; Roy van der Meel; Roy van der Meel; Sam Chen; Josh Zaifman; Jayesh A. Kulkarni; Xu Ran Sabrina Zhang; Ying K. Tam; Marcel B. Bally; Raymond M. Schiffelers; Marco A. Ciufolini; Pieter R. Cullis; Yuen Yi C. Tam:
  Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery
  Small 17/37, 2103025, 10.1002/smll.202103025
  
  
• Daniel E. Murphy, Olivier G. de Jong, Martijn J. W. Evers, Maratussholikhah Nurazizah, Raymond M. Schiffelers, Pieter Vader:
  Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles
  Nano Letters 21/4, 1888-1895, 10.1021/acs.nanolett.1c00094
  
  
• Helena Sork; Mariana Conceicao; Giulia Corso; Joel Nordin; Yi Xin Fiona Lee; Kaarel Krjutskov; Jakub Orzechowski Westholm; Pieter Vader; Marie Pauwels; Roosmarijn E. Vandenbroucke; Matthew JA Wood; Samir EL Andaloussi; Imre Mäger:
  Profiling of Extracellular Small RNAs Highlights a Strong Bias towards Non-Vesicular Secretion
  Cells 10(6), 1543, 10.3390/cells10061543
  
  
• Hannah Walgrave, Lujia Zhou, Bart De Strooper, Evgenia Salta:
  The promise of microRNA-based therapies in Alzheimer's disease: challenges and perspectives
  Molecular Neurodegeneration 16, Article number: 76 (2021), 10.1186/s13024-021-00496-7
  
  

2020

• de Jong, Olivier G.; Murphy, Daniel E.; Mäger, Imre; Willms, Eduard; Garcia-Guerra, Antonio; Gitz-Francois, Jerney J.; Lefferts, Juliet; Gupta, Dhanu; Steenbeek, Sander C.; van Rheenen, Jacco; El Andaloussi, Samir; Schiffelers, Raymond M.; Wood, Matthew J. A.; Vader, Pieter:
  A CRISPR-Cas9-based reporter system for single-cell detection of extracellular vesicle-mediated functional transfer of RNA
  Nature Communications 3, 10.1038/s41467-020-14977-8
  
  
• Eleni Samaridou, Hannah Walgrave, Evgenia Salta, David Moreira Álvarez, Vanessa Castro, Mabel Loza, Bart De Strooper, Maria José Alonso:
  Nose-to-brain delivery of enveloped RNA - cell permeating peptide nanocomplexes for the treatment of neurodegenerative diseases
  Biomaterials 230, 119657, 10.1016/j.biomaterials.2019.119657
  
  

2019

• Olivier G. de Jong, Sander A. A. Kooijmans, Daniel E. Murphy, Linglei Jiang, Martijn J. W. Evers, Joost P. G. Sluijter, Pieter Vader, Raymond M. Schiffelers:
  Drug Delivery with Extracellular Vesicles: From Imagination to Innovation
  Accounts of Chemical Research 52/7, 1761-1770, 10.1021/acs.accounts.9b00109
  
  
• Daniel E. Murphy, Olivier G. de Jong, Maarten Brouwer, Matthew J. Wood, Grégory Lavieu, Raymond M. Schiffelers, Pieter Vader:
  Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking
  Experimental & Molecular Medicine 51/3, 10.1038/s12276-019-0223-5
  
  

2018

• Willms E, Cabañas C, Mäger I, Wood MJA, Vader P:
  Extracellular Vesicle Heterogeneity: Subpopulations, Isolation Techniques, and Diverse Functions in Cancer Progression
  Front Immunol Apr 30;9:738, 10.3389/fimmu.2018.00738
  
  
• Sork H, Corso G, Krjutskov K, Johansson HJ, Nordin JZ, Wiklander OPB, Lee YXF, Westholm JO, Lehtiö J, Wood MJA, Mäger I, El Andaloussi S:
  Heterogeneity and interplay of the extracellular vesicle small RNA transcriptome and proteome.
  Scientific Reports 2018 Jul 17; 8(1), 10813, 10.1038/s41598-018-28485-9
  
  
• Martijn J. W. Evers Jayesh A. Kulkarni Roy van der Meel Pieter R. Cullis Pieter Vader Raymond M. Schiffelers:
  State‐of‐the‐Art Design and Rapid‐Mixing Production Techniques of Lipid Nanoparticles for Nucleic Acid Delivery
  Small Methods, 10.1002/smtd.201700375
  
  

2017

• O'Loughlin AJ, Mäger I, de Jong OG, Varela MA, Schiffelers RM, El Andaloussi S, Wood MJA, Vader P:
  Functional Delivery of Lipid-Conjugated siRNA by Extracellular Vesicles
  Molecular Therapy, dx.doi.org/10.1016/j.ymthe.2017.03.021
  
  
• Eleni Samaridou and María José Alonso:
  Nose-to-brain peptide delivery – the potential of nanotechnology
  Bioorganic & Medicinal Chemistry